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Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different <t>dexamethasone</t> formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.
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Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different <t>dexamethasone</t> formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.
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Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different <t>dexamethasone</t> formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.
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Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different <t>dexamethasone</t> formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.
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Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different <t>dexamethasone</t> formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.
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Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different dexamethasone formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.

Journal: Materials Today Bio

Article Title: Enhancing the therapeutic efficacy of dexamethasone for oral ulcers through adhesive gelatin hydrogel-based nano-delivery system

doi: 10.1016/j.mtbio.2026.103341

Figure Lengend Snippet: Therapeutic efficacy of gelatin hydrogel loaded with PDA-Dex-PAN on rat oral ulcers. (a) Schematic diagram of oral ulcer induction and drug administration in rat. (b) Therapeutic effects of different dexamethasone formulations on rat oral ulcers. A total of six replicates are present. The figure above shows three of them, and the other three replicates are provided in Serum levels of inflammatory cytokines, including IL-6 (c), TNF-α (d), and IL-1β (e), in rats after treatment with different dexamethasone formulations. The data are represented as mean ± SD (n = 6). The difference analyses were performed using the Student's t-test, and the significance was indicated by one asterisk for p < 0.05 and two asterisks for p < 0.01. (f) H&E staining observation of the ulcer sites in rat oral mucosa after treatment with different dexamethasone formulations.

Article Snippet: The following reagents were obtained from the specified suppliers: dexamethasone (Dex), rhodamine (RhB) and dopamine (PDA) from Shanghai Yuanye Biological Technology Co., Ltd. (Shanghai, China); gelatin (Type B), poly-L-lysine (PLL), and polyethylene glycol (PEG6000) from Aladdin Bio-Chem Technology Co., Ltd. (Shanghai, China); glycine from Shanghai Sangon (Shanghai, China); polylactic acid (Mw 18-24 kDa), 4′,6-Diamidino-2-phenylindole (DAPI), phosgene, 2-hydroxyethyl disulfide, THF, NHS ester, and triethylamine from Sigma-Aldrich (St. Louis, USA).

Techniques: Drug discovery, Staining